| 2022-06-09 21:00:00June 9, 2022 | MTL  | 27 - 30 |  CGY | McMahon Stadium |
| 2022-06-10 20:30:00June 10, 2022 | OTT  | 17 - 19 |  WPG | IG Field |
| 2022-06-11 19:00:00June 11, 2022 | HAM  | 13 - 30 |  SSK | Mosaic Stadium |
| 2022-06-11 22:00:00June 11, 2022 | EDM  | 15 - 59 |  BC | BC Place |
| 2022-06-16 19:30:00June 16, 2022 | MTL | 19 - 20 |  TOR | BMO Field |
| 2022-06-17 19:30:00June 17, 2022 | WPG | 19 - 12 | OTT | TD Place Stadium |
| 2022-06-18 18:30:00June 18, 2022 | CGY | 33 - 30 | HAM | Tim Hortons Field |
| 2022-06-18 21:30:00June 18, 2022 | SSK | 26 - 16 | EDM | Commonwealth Stadium |
| 2022-06-23 19:30:00June 23, 2022 | SSK | 13 - 37 | MTL | Percival Molson Memorial Stadium |
| 2022-06-24 20:30:00June 24, 2022 | HAM | 12 - 26 | WPG | IG Field |
| 2022-06-25 19:00:00June 25, 2022 | EDM | 23 - 30 | CGY | McMahon Stadium |
| 2022-06-25 22:00:00June 25, 2022 | TOR | 3 - 44 | BC | BMO Field |
| 2022-06-30 19:30:00June 30, 2022 | BC | 34 - 31 | OTT | TD Place Stadium |
| 2022-07-01 19:30:00July 1, 2022 | EDM | 29 - 25 | HAM | Commonwealth Stadium |
| 2022-07-02 19:00:00July 2, 2022 | MTL | 20 - 41 | SSK | Percival Molson Memorial Stadium |
| 2022-07-04 19:30:00July 4, 2022 | WPG | 23 - 22 | TOR | IG Field |
| 2022-07-07 21:00:00July 7, 2022 | CGY | 49 - 6 | EDM | Commonwealth Stadium |
| 2022-07-08 21:30:00July 8, 2022 | OTT | 13 - 28 | SSK | Mosaic Stadium |
| 2022-07-09 19:00:00July 9, 2022 | WPG | 43 - 22 | BC | IG Field |
| 2022-07-14 19:30:00July 14, 2022 | EDM | 32 - 31 | MTL | Commonwealth Stadium |
| 2022-07-15 20:30:00July 15, 2022 | CGY | 19 - 26 | WPG | IG Field |
| 2022-07-16 16:00:00July 16, 2022 | OTT | 23 - 25 | HAM | Tim Hortons Field |
| 2022-07-16 19:00:00July 16, 2022 | SSK | 24 - 30 | TOR | Mosaic Stadium |
| 2022-07-21 19:00:00July 21, 2022 | MTL | 40 - 33 | OTT | TD Place Stadium |
| 2022-07-21 22:00:00July 21, 2022 | HAM | 12 - 17 | BC | Tim Hortons Field |
| 2022-07-22 21:00:00July 22, 2022 | WPG | 24 - 10 | EDM | Commonwealth Stadium |
| 2022-07-23 19:00:00July 23, 2022 | TOR | 31 - 21 | SSK | Mosaic Stadium |
| 2022-07-28 19:30:00July 28, 2022 | MTL | 17 - 24 | HAM | Percival Molson Memorial Stadium |
| 2022-07-29 21:00:00July 29, 2022 | BC | 32 - 17 | SSK | Mosaic Stadium |
| 2022-07-30 19:00:00July 30, 2022 | WPG | 35 - 28 | CGY | McMahon Stadium |
| 2022-07-31 17:00:00July 31, 2022 | OTT | 23 - 13 | TOR | BMO Field |
| 2022-08-04 19:30:00August 4, 2022 | WPG | 35 - 20 | MTL | IG Field |
| 2022-08-05 19:30:00August 5, 2022 | CGY | 17 - 3 | OTT | TD Place Stadium |
| 2022-08-06 19:00:00August 6, 2022 | HAM | 20 - 34 | TOR | BMO Field |
| 2022-08-06 22:00:00August 6, 2022 | EDM | 14 - 46 | BC | BC Place |
| 2022-08-11 20:30:00August 11, 2022 | MTL | 20 - 17 | WPG | IG Field |
| 2022-08-12 19:30:00August 12, 2022 | TOR | 27 - 34 | HAM | Tim Hortons Field |
| 2022-08-13 19:00:00August 13, 2022 | BC | 41 - 40 | CGY | McMahon Stadium |
| 2022-08-13 19:00:00August 13, 2022 | SSK | 34 - 23 | EDM | Mosaic Stadium |
| 2022-08-19 19:00:00August 19, 2022 | EDM | 30 - 12 | OTT | Commonwealth Stadium |
| 2022-08-19 22:00:00August 19, 2022 | BC | 28 - 10 | SSK | Mosaic Stadium |
| 2022-08-20 16:00:00August 20, 2022 | HAM | 28 - 29 | MTL | Percival Molson Memorial Stadium |
| 2022-08-20 19:00:00August 20, 2022 | CGY | 22 - 19 | TOR | McMahon Stadium |
| 2022-08-25 20:30:00August 25, 2022 | CGY | 29 - 31 | WPG | IG Field |
| 2022-08-26 19:30:00August 26, 2022 | HAM | 20 - 37 | TOR | Tim Hortons Field |
| 2022-08-26 22:30:00August 26, 2022 | SSK | 23 - 16 | BC | Mosaic Stadium |
| 2022-08-27 19:00:00August 27, 2022 | OTT | 25 - 18 | EDM | Commonwealth Stadium |
| 2022-09-02 19:30:00September 2, 2022 | OTT | 38 - 24 | MTL | TD Place Stadium |
| 2022-09-04 18:00:00September 4, 2022 | WPG | 20 - 18 | SSK | Mosaic Stadium |
| 2022-09-05 13:00:00September 5, 2022 | TOR | 28 - 8 | HAM | Tim Hortons Field |
| 2022-09-05 16:30:00September 5, 2022 | EDM | 18 - 28 | CGY | McMahon Stadium |
| 2022-09-09 19:30:00September 9, 2022 | BC | 10 - 31 | MTL | Percival Molson Memorial Stadium |
| 2022-10-29 14:00:00October 29, 2022 | MTL | 38 - 33 | TOR | BMO Field |
| 2022-10-29 17:00:00October 29, 2022 | HAM | 23 - 16 | OTT | TD Place Stadium |
| 2022-10-29 20:00:00October 29, 2022 | SSK | 10 - 36 | CGY | McMahon Stadium |
